A humanized single-chain antibody against beta 3 integrin inhibits pulmonary metastasis by preferentially fragmenting activated platelets in the tumor microenvironment Abbreviated Title: Human Anti-GPIIIa Ab inhibits pulmonary metastasis
نویسندگان
چکیده
Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai 200062, P.R.China; Department of Medical Genetics, Shanghai Jiao Tong University School of Medicine, Shanghai 200025; Shanghai key laboratory of brain Functional Genomics, East China Normal University, Shanghai 200062, P.R.China; Shanghai Engineering Research Center of Molecular Therapy and Pharmaceutical Innovation, Shanghai 200062, P.R.China; Departments of Neurology, Pathology and Psychiatry, New York University School of Medicine, New York, NY 10016, USA
منابع مشابه
A humanized single-chain antibody against beta 3 integrin inhibits pulmonary metastasis by preferentially fragmenting activated platelets in the tumor microenvironment.
Platelets play a supportive role in tumor metastasis. Impairment of platelet function within the tumor microenvironment may provide a clinically useful approach to inhibit metastasis. We developed a novel humanized single-chain antibody (scFv Ab) against integrin GPIIIa49-66 (named A11) capable of lysing activated platelets. In this study, we investigate the effect of A11 on the development of ...
متن کاملTHROMBOSIS AND HEMOSTASIS A humanized single-chain antibody against beta 3 integrin inhibits pulmonary metastasis by preferentially fragmenting activated platelets in the tumor microenvironment
1Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, People’s Republic of China; 2Shanghai Engineering Research Center of Molecular Therapy and Pharmaceutical Innovation, Shanghai, People’s Republic of China; 3Department of Medical Genetics, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 4Shanghai Key Laboratory of...
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